The Role of GnRH Analogue Treatment before and after Laparoscopy

Introduction
Gonadotropin releasing hormone (GnRH) is a decapeptide produced by the hypothalamus. Hypothalamus is the highest center within the brain organizing several important functions, consisting of neuroendocrine cells producing five neurohormones. GnRH is one of those neurohormones, produced by arcuate nucleus.1,2

Trials in rats showed that there are two centers within the hypothalamus having different functions. These are tonic center located in the ventromedial of arcuate nucleus and cyclic center located in the preoptical area near the suprachiamic center in the anterior part of the hypothalamus. Cyclic center functioned to control LH release in the mid-cycle, whereas tonic center is responsible to fulfill daily basal gonadotropin requirement.1,2

Within the hypothalamic tissue, GnRH level is low, so that extraction is difficult and destruction by peptidase is more straightforward, therefore in favor of treatment GnRH analogue was made consisting of GnRH agonist and antagonist.